منابع مشابه
Biology and Biomarkers for Wound Healing WOUND HEALING
www.PRSJournal.com 18S Wound healing is a multifaceted process governed by sequential yet overlapping phases, including hemostasis, inflammation, proliferation, and remodeling. This process is executed through communication between the various local skin compartments, supporting extracellular matrix, and systemic contributors. Under physiological conditions in a healthy individual, the process ...
متن کاملProteolytic events of wound-healing--coordinated interactions among matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules.
During wound-healing, cells are required to migrate rapidly into the wound site via a proteolytically generated pathway in the provisional matrix, to produce new extracellular matrix, and, subsequently, to remodel the newly formed tissue matrix during the maturation phase. Two classes of molecules cooperate closely to achieve this goal, namely, the matrix adhesion and signaling receptors, the i...
متن کاملMatrix metalloproteinases and their roles in poor wound healing in diabetes
Amongst the many other chronic complications, diabetes can cause impaired wound healing and, with it, increased morbidity. Up to 25% of all patients with diabetes will develop a foot ulcer and, each year in Australia, approximately 3000 persons with diabetes require amputation secondary to foot ulceration 1. The essential components of diabetic foot ulcer treatment include increasing blood supp...
متن کاملDifferential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing.
OBJECT Matrix metalloproteinases (MMPs), particularly MMP-9/gelatinase B, promote early inflammation and barrier disruption after spinal cord injury (SCI). Early blockade of MMPs after injury provides neuroprotection and improves motor outcome. There is recent evidence, however, that MMP-9 and MMP-2/gelatinase A participate in later wound healing in the injured cord. The authors therefore exami...
متن کاملElevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence.
OBJECTIVE In the past 20 years, research and clinical trials on the healing process of chronic wounds have highlighted the key role of the family of enzymes called matrix metalloproteinases (MMPs). If a strong correlation between the course of healing of chronic wounds and the levels of a biological marker can be demonstrated, then it may be possible to: i) identify the best marker threshold to...
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ژورنال
عنوان ژورنال: Advances in Wound Care
سال: 2015
ISSN: 2162-1918,2162-1934
DOI: 10.1089/wound.2014.0581